Vegan Diet Outperforms Mediterranean Diet for Weight Loss

By Liis Hainla. Updated: August 2024.
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Recent research from the Physicians Committee for Responsible Medicine (PCRM) has uncovered compelling evidence that a low-fat vegan diet is more effective than a Mediterranean diet for reducing harmful dietary compounds and achieving weight loss.

Published in Frontiers in Nutrition, the study demonstrates that adopting a low-fat vegan diet significantly lowers advanced glycation end-products (AGEs)—compounds associated with inflammation and weight gain—by 73%. This contrasts with the Mediterranean diet, which showed no significant reduction in AGEs.

The Impact of AGEs on Your Health and Weight

AGEs are toxic compounds that build up in the body from specific dietary sources, especially animal products and foods cooked at high temperatures. These compounds are notorious for contributing to insulin resistance, chronic inflammation, and serious health issues like obesity and type 2 diabetes. 

The study revealed that those on the vegan diet lost an average of 13 pounds, while participants on the Mediterranean diet saw no change in their weight. By lowering AGEs, the vegan diet not only facilitates effective weight management but also supports overall better health.

What the Study Reveals About Dietary Choices

The research highlights that the dramatic reduction in AGEs with a vegan diet comes from eliminating meat (which accounts for 41% of AGE intake), reducing added fats (27%), and cutting out dairy products (14%). In contrast, the Mediterranean diet, which includes higher amounts of fats and dairy, proves less effective at lowering AGE levels.

Expert Insights on the Vegan Diet Advantage

Dr. Hana Kahleova, MD, PhD, and the lead author of the study, comments: “Our findings challenge the assumption that the Mediterranean diet is the ultimate choice for weight loss. The low-fat vegan diet, by cutting out common AGE sources like dairy and oils, not only decreases harmful compounds but also results in substantial weight loss.”

Study Methodology and Key Takeaways

Participants in the study followed either a low-fat vegan diet or a Mediterranean diet for 16 weeks. After a washout period, they switched to the other diet for another 16 weeks. AGEs were measured based on their reported food intake and a published AGE content database.

Dr. Kahleova concludes, “Our research confirms that a diet rich in fruits, vegetables, grains, and beans while low in AGEs is an effective, straightforward method for weight management and chronic disease prevention. It’s a tasty and powerful approach to maintaining a healthy weight.”

For those eager to find a diet that not only enhances weight loss but also combats inflammation and chronic health issues, the low-fat vegan diet offers a compelling and effective alternative.

My name is Liis. I've been a vegan for a long time and advocate for the vegan lifestyle. Through Vegan Avenue, I write about the latest vegan news, trends, events, and all things related to the vegan lifestyle.